ABSTRACT

The solubility of pyrazinamide in ten solvents (water, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, acetonitrile and ethyl acetate) at temperatures ranging from (278.15 to 323.15) K was determined by using the gravimetric method. The experimental results indicated that in different solvents, the solubility of pyrazinamide was temperature dependent and increased with the increasing temperature. Besides, the modified Apelblat equation, kh equation, Wilson model and NRTL model were employed to correlate the solubility data in the solvents. The results show that the correlated data are in good agreement with the experimental solubility. Furthermore, the mixing thermodynamic properties of pyrazinamide in different solvents were calculated based on the Wilson model. The outcome indicates that the mixing process of pyrazinamide is endothermic.

Compounds

#	Formula	Name
1	H2O	water
2	C5H5N3O	pyrazinecarboxamide
3	CH4O	methanol
4	C2H6O	ethanol
5	C3H8O	propan-1-ol
6	C3H8O	propan-2-ol
7	C4H10O	butan-1-ol
8	C4H10O	butan-2-ol
9	C3H6O	acetone
10	C2H3N	acetonitrile
11	C4H8O2	ethyl acetate

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric method	10
POMD	3 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	9
POMD	4 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	9
POMD	5 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	10
POMD	6 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	10
POMD	7 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	10
POMD	8 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	10
POMD	9 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	10
POMD	10 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric	10
POMD	2 11	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	gravimetric method	10

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Thermodynamic study of solubility for pyrazinamide in ten solvents from T = (283.15 to 323.15) K

Zhang, K.[Keke], Shen, H.[Huan], Xu, S.[Shijie], Zhang, H.[Huihui], Zhu, M.[Minghe], Shi, P.[Peng], Fu, X.[Xiaoyan], Yang, Y.[Yaoyao], Gong, J.[Junbo]

ABSTRACT