ABSTRACT

In the present work the temperature dependence of heat capacity for methylprednisolone has been measured for the first time over the temperature range from 6 to 350 K using by precision adiabatic vacuum calorimetry. Based on the experimental data, the thermodynamic functions of the methylprednisolone, namely, the heat capacity, enthalpy H (T) - H (0), entropy S (T) - S (0) and Gibbs function G (T) - H (0) have been evaluated from the experimental values for the range from T0 to 350 K. Standard molar enthalpy of combustion ( 11898.9 +- 6.7) kJ mol 1 of the methylprednisolone was measured for the first time using high-precision combustion calorimeter. The standard molar enthalpy of formation in the crystalline state ( 1045.8 +- 7.3) kJ mol-1 of compound at 298.15 K was derived from the combustion experiments. The standard molar enthalpy of sublimation at 298.15 K (194.5 +- 2.2) kJ mol-1 was measured by using the quartz-crystal microbalance (QCM). Using combination of the adiabatic and combustion calorimetry with the result from QCM, the thermodynamic functions of the methylprednisolone at T = 298.15 K and p = 0.1 MPa have been calculated.

Compounds

#	Formula	Name
1	CO2	carbon dioxide
2	H2O	water
3	O2	oxygen
4	C22H30O5	Methylprednisolone

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	4	Molar enthalpy of vaporization or sublimation, kJ/mol ; Crystal	Temperature, K; Crystal		Crystal Gas	Derived by Second law	1
POMD	4	Molar heat capacity at constant pressure, J/K/mol ; Crystal	Temperature, K; Crystal	Pressure, kPa; Crystal	Crystal	Small (less than 1 g) adiabatic calorimetry	41
POMD	4	Molar enthalpy, kJ/mol ; Crystal	Temperature, K; Crystal	Pressure, kPa; Crystal	Crystal	Small (less than 1 g) adiabatic calorimetry	41
POMD	4	Molar entropy, J/K/mol ; Crystal	Temperature, K; Crystal	Pressure, kPa; Crystal	Crystal	Small (less than 1 g) adiabatic calorimetry	41
POMD	4	Molar heat capacity at constant pressure, J/K/mol ; Crystal	Temperature, K; Crystal	Pressure, kPa; Crystal	Crystal	Small (less than 1 g) adiabatic calorimetry	126
RXND	4 1 2 3	Specific internal energy of reaction at constant volume, J/g				Static bomb calorimetry	1

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Comprehensive thermodynamic study of methylprednisolone

Knyazev, A. V., Emel'yanenko, V. N., Smirnova, N. N., Zaitsau, D. H., Stepanova, O. V., Shipilova, A. S., Markin, A. V., Gusarova, E. V., Knyazeva, S. S., Verevkin, S. P.

ABSTRACT