ABSTRACT

Solubility measurements at equilibrium were performed for the systems (3beta,25R)-spirost-5-en-3-ol (diosgenin) and (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol (estriol) in at least 12 solvents at atmospheric pressure within the temperature range T = (293.2 328.2 K) using combined digital thermal analysis and thermal gravimetric analysis (DTA/TGA) to determine compositions at saturation. The results were modelled with the NRTL and Tsuboka-Katayma modified Wilson activity coefficient models. The models employed provided a satisfactory correlation of the experimental data. Furthermore melting points and enthalpies of melting of diosgenin and estriol were determined by combined DTA/TGA.

Compounds

#	Formula	Name
1	C9H20O	nonan-1-ol
2	C5H12O	pentan-1-ol
3	C2H3N	acetonitrile
4	C2H7NO	2-aminoethan-1-ol
5	C12H26	dodecane
6	C4H10O	butan-2-ol
7	C3H7NO	dimethylformamide
8	C8H18	octane
9	C8H18O	octan-1-ol
10	C5H9NO2	N-formylmorpholine
11	C16H34	hexadecane
12	C5H9NO	N-methylpyrrolidone
13	H2O	water
14	C27H42O3	Diosgenin
15	C18H24O3	Estriol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	14	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	14	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	15	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	15	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	1 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	4 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	3 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	5 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	6 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	7 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	8 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	14 13	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	9 14	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	14 10	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	14 11	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	14 12	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	DTA/TGA	8
POMD	15 1	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 2	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 4	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 5	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 6	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 7	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 8	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 13	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 9	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 10	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 11	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8
POMD	15 12	Mole fraction - 15 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 15	DTA/TGA	8

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Experimental solubility of diosgenin and estriol in various solvents between T = (293.2-328.2) K

Moodley, K.[Kuveneshan], Rarey, J.[Jurgen], Ramjugernath, D.[Deresh]

ABSTRACT