Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

ABSTRACT

In this work, the solubility of the form A of ibrutinib in isopropanol (IPA), 1-butanol, ethyl acetate (EA), acetonitrile, acetone, methyl ethyl ketone (MEK) and methyl tertiary butyl ether (MTBE) was firstly experimentally determined by a gravimetric method in the temperature range from 278.15 to 323.15 K at atmospheric pressure. The experimental solubility data were correlated by several commonly used models including the modified Apelblat equation, the Buchowski-Ksiazczak kh equation and an empirical quartic polynomial equation. The results showed that, in the temperature range investigated, the solubility of ibrutinib generally increased with the increasing temperature, and the solubility order at the room temperature in the studied solvents was: MEK greater than acetone greater than ethyl acetate greater than 1-butanol greater than acetonitrile isopropanol greater than MTBE. In addition, all the models gave satisfactory correlation results, in which the empirical quartic polynomial equation stood out to be more suitable with a higher accuracy than the other two equations.