Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

ABSTRACT

The solubility of 1,3-diphenylguanidine was determined in ethanol, isopropanol, n-propanol, n-butanol, i-butanol, ethyl acetate, toluene, acetone and acetonitrile by a high performance liquid chromatography (HPLC) within temperature range from (273.15 to 313.15) K under pressure of 101.3 kPa. The solubility of 1,3-diphenylguanidine in the selected solvents increased with the increase in temperature. On the whole, the solubility of 1,3-diphenylguanidine in these solvents followed the order: acetone greater than ethyl acetate greater than n-butanol greater than n-propanol greater than ethanol greater than i-butanol greater than acetonitrile greater than isopropanol greater than toluene. The acquired solubility of 1,3-diphenylguanidine were correlated with the Apelblat equation, kh equation, Wilson model and NRTL model, and the corresponding model parameters were obtained. The Apelblat equation provided better results than the other three models. Furthermore, the apparent dissolution enthalpy and excess enthalpy of solution were obtained from the experimental solubility. The solubility would be helpful in optimising the purification process of 1,3-diphenylguanidine on the industrial scale.