ABSTRACT

The interactions of L-serine and L-threonine with drug metformin hydrochloride (Metformin-HCl) as a function of temperature have been investigated by combination of volumetric and acoustic methods. Densities and speeds of sound of L-serine and L-threonine in (0.00, 0.03, 0.045, 0.06 and 0.09) mol kg 1 aqueous solutions of Metformin-HCl have been measured at T = (305.15, 310.15 and 315.15) K and experimental pressure p = 0.1 MPa. The apparent molar volume V/, the partial molar volume V / and standard partial molar volumes of transfer DV / for L-serine and L-threonine from water to aqueous Metformin-HCl solutions have been calculated from density data. Partial molar isentropic compression K/;s and partial molar isentropic compression of transfer DK /;s have been calculated from speed of sound data. The pair and triplet interaction coefficient have also been calculated. The results have been explained based on competing patterns of interactions of co-solvents and the solute.

Compounds

#	Formula	Name
1	C3H7NO3	L-serine
2	C4H9NO3	L-threonine
3	C4H12ClN5	N,N-dimethylimidodicarbonimidic diamide hydrochloride
4	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 3 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	165
POMD	1 3 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	165
POMD	2 3 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	165
POMD	2 3 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	165
POMD	1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	33
POMD	1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	33
POMD	3 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	3 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	16
POMD	2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	33
POMD	2 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	33

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Effect of L-serine and L-threonine on volumetric and acoustic behaviour of aqueous metformin hydrochloride solutions at T = (305.15, 310.15 and 315.15) K

Kumar, H.[Harsh], Behal, I.[Isha], Singla, M.[Meenu]

ABSTRACT