ABSTRACT

The solubility of diphenhydramine hydrochloride (DH) in four pure solvents (methanol, ethanol, acetone and ethyl acetate) and two binary solvents (ethanol + ethyl acetate) and (ethanol + acetone) was determined at temperatures from (278.15 to 323.15) K. The experimental solubility of DH is well correlated by the modified Apelblat equation, the CNIBS/R-K equation and the hybrid model, respectively. All the measured solubility of DH shows temperature dependence. In binary mixtures, the solubility curve displays a maximum with the solvent composition changing, particularly, the maximum point increases with temperature. Moreover, the activity coefficients as well as thermodynamic properties of mixing were obtained and discussed.

Compounds

#	Formula	Name
1	C17H22ClNO	2-diphenylmethoxy-N,N-dimethylethanamine hydrochloride
2	C2H6O	ethanol
3	C3H6O	acetone
4	C4H8O2	ethyl acetate
5	CH4O	methanol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	1	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	2 4 1	Mole fraction - 1 ; Liquid	Solvent: Mole fraction - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	110
POMD	2 3 1	Mole fraction - 1 ; Liquid	Solvent: Mole fraction - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	110

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Correlation and thermodynamic analysis of solubility of diphenhydramine hydrochloride in pure and binary solvents

Du, S.[Shichao], Wang, Y.[Yan], Li, J.[Jianyu], Wu, S.[Songgu], Dun, W.[Weiqiang], Song, X.[Xiaopeng], Wang, J.[Jingkang], Gong, J.[Junbo]

ABSTRACT