ABSTRACT

Densities and speeds of sound of diphenhydramine hydrochloride (DPH) in aqueous solution and 0.06 mol kg 1 aqueous solutions of sodium chloride and myo-inositol (MI) have been measured at different temperatures, T = (288.15, 298.15 and 308.15) K over the concentration range (0.01 to 0.1) mol kg 1. Density and speed of sound values were used to evaluate thermodynamic properties such as apparent molar volume (V/), isentropic compressibility (js) of solution, apparent molar isentropic compressibility (j/) of solute, of diphenhydramine hydrochloride in water and in aqueous solutions of sodium chloride and myo-inositol. The limiting apparent molar expansivity dE0 /T of solute and coefficient of thermal expansion (a.) of DPH in aqueous binary and ternary solutions have also been computed. Limiting values of apparent molar volume dV0 /T and apparent molar compressibility dj0 /T were obtained from the plots V/ and j/ as a function of molality and have been utilized in obtaining transfer volumes dDtrV0 /T and transfer compressibilities dDtrj0 /T of diphenhydramine hydrochloride from water to aqueous solutions of sodium chloride and myo-inositol at different temperatures. The transfer volume and transfer compressibility at infinite dilution calculated from dV0 /T and dj0 /T were found to have positive values. The results obtained have been interpreted in terms of various interactions taking place among solute and solvent molecules.

Compounds

#	Formula	Name
1	C17H22ClNO	2-diphenylmethoxy-N,N-dimethylethanamine hydrochloride
2	ClNa	sodium chloride
3	C6H12O6	cis-1,2,3,5-trans-4,6-cyclohexanehexol
4	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Pycnometric method	3
POMD	4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	3
POMD	1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Pycnometric method	45
POMD	1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	45
POMD	1 2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Solvent: Molality, mol/kg - 2; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	45
POMD	1 2 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Solvent: Molality, mol/kg - 2; Liquid Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	45
POMD	3 1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Solvent: Molality, mol/kg - 3; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	45
POMD	3 1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Solvent: Molality, mol/kg - 3; Liquid Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	45
POMD	2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Molality, mol/kg - 2; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	3
POMD	2 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Molality, mol/kg - 2; Liquid Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	3
POMD	3 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Molality, mol/kg - 3; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	3
POMD	3 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Molality, mol/kg - 3; Liquid Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	3

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Effect of sodium chloride and myo-inositol on diphenhydramine hydrochloride drug in aqueous solution at different temperatures: Volumetric and acoustic approach

Jengathe, S. P.[Santosh P.], Dhondge, S. S.[Sudhakar S.], Paliwal, L. J.[Lalitmohan J.], Tangde, V. M.[Vijay M.], Mondal, S.[Sudip]

ABSTRACT