Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

ABSTRACT

The solubility of rutaecarpine and evodiamine was measured in (ethanol + water) mixed solvents with different values of mole fraction ethanol from (u = 0.30 to 0.80) over the temperature range of (T = 288.2, 298.2, 308.2, 318.2 and 328.2) K. With increasing temperature and mole fraction ethanol, the solubility of rutaecarpine and evodiamine increased. The experimental solubility values were well correlated by the modified Apelblat equation, simplified thermodynamic equation and semi-empirical Buchowski Ksiazczak kh equation. The correlated results by the modified Apelblat equation were better than those by other two equations. The enthalpy of dissolution (DdisHo) and entropy of dissolution (DdisSo) of rutaecarpine and evodiamine during the dissolution process in (ethanol + water) mixed solvents were calculated by the van t Hoff equation. The results indicate that the dissolution process is endothermic and entropy-driven.