ABSTRACT

Apparent molar volume (V2,/) and apparent molar isentropic compressibility (Ks,2,/) of diclofenac sodium salt (DSS) drug within the concentration range of (0.001 to 0.008) mol kg 1 in (0.01, 0.03 and 0.05) mol kg 1 aqueous glycine and L-proline solutions are computed from the experimental density (q) and speed of sound (u) values at T = (293.15 to 313.15) K and atmospheric pressure. Derived parameters such as partial molar properties, transfer partial molar properties, hydration numbers and Hepler s constant are computed from the data of V2,/ and Ks,2,/. These parameters have been used to understand the effect of temperature on interactions between DSS drug and aqueous glycine/L-proline solution. Furthermore, the structure making and breaking ability of DSS drug in probed solutions are analysed at experimental conditions.

Compounds

#	Formula	Name
1	H2O	water
2	C14H10Cl2NNaO2	sodium diclofenac
3	C2H5NO2	2-aminoacetic acid
4	C5H9NO2	L-proline

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	5
POMD	1	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	5
POMD	3 1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	205
POMD	3 1 2	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	205
POMD	4 1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	205
POMD	4 1 2	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	205
POMD	1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	50
POMD	1 2	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	50
POMD	3 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	3 1	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15
POMD	4 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	4 1	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Effect of temperature on solvation behaviour of diclofenac sodium salt in aqueous glycine and L-proline solutions

Ryshetti, S.[Suresh], Gardas, R. L.[Ramesh L.], Tangeda, S. J.[Savitha Jyostna]

ABSTRACT