ABSTRACT

In order to add to the existing knowledge of aqueous solution behavior of bile salts in presence of amino acids, the micellization properties of sodium cholate (NaC) (1 to 20) mmol kg 1, and sodium deoxycholate (NaDC) (0.5 to 10) mmol kg 1 in 0.1 mol kg 1 aqueous solution of glycine, leucine, methionine, and histidine have been investigated at different temperatures (293.15 to 318.15) K at intervals of T = 5 K by using conductivity and fluorescence probe studies. The critical micelle concentration (CMC) values have been determined and elucidated in terms of hydrophobicity as well as hydrophilicity of NaC and NaDC in aqueous solution of these additives. Thermodynamic parameters of micellization viz. standard Gibbs free energy (DmicGo), standard enthalpy (DmicHo), and standard entropy (DmicSo) have also been calculated to extract information regarding the nature of micellization of bile salts in aqueous solutions. The (enthalpy + entropy) compensation plots have been interpreted to the contribution of chemical part towards micellization or stability of the micelle formed.

Compounds

#	Formula	Name
1	C24H39NaO5	sodium cholate
2	C24H39NaO4	sodium deoxycholate
3	C2H5NO2	2-aminoacetic acid
4	C6H13NO2	L-leucine
5	C5H11NO2S	L-methionine
6	C6H9N3O2	L-histidine
7	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	6 1 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 6; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	3 1 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 3; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	5 1 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 5; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	4 1 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 4; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	6 2 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 6; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	3 2 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 3; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	5 2 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 5; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	4 2 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Solvent: Molality, mol/kg - 4; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	1 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Alternating current cell with electrodes	120
POMD	2 7	Electrical conductivity, S/m ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Alternating current cell with electrodes	120

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Conductivity and fluorescence studies on the micellization properties of sodium cholate and sodium deoxycholate in aqueous medium at different temperatures: Effect of selected amino acids

Kumar, K.[Kuldeep], Patial, B. S.[Baljeet S.], Chauhan, S.[Suvarcha]

ABSTRACT