ABSTRACT

The interactions of PAMAM-NH2 G4 dendrimer with selected natural amino acids (Gly, Ala, Val, Leu, Ile, Phe, Ser, Thr, Met, Asn, Gln, Pro and Trp) in aqueous solutions were measured with the use of the techniques of calorimetric titration and dilution calorimetry. The results of calorimetric measurements show strong interactions between PAMAM-NH2 G4 dendrimer and amino acids with polar substituents. A macromolecule of PAMAM-NH2 G4 dendrimer can coordinate 20 to 40 molecules of amino acid

Compounds

#	Formula	Name
1	C6H13NO2	L-leucine
2	C6H13NO2	2-amino-3-methylpentanoic acid
3	C5H11NO2	L-valine
4	C3H7NO2	(S)-2-aminopropanoic acid
5	C9H11NO2	L-phenylalanine
6	C11H12N2O2	L-tryptophan
7	C5H11NO2S	L-methionine
8	C5H9NO2	L-proline
9	C4H9NO3	L-threonine
10	C2H5NO2	2-aminoacetic acid
11	C3H7NO3	L-serine
12	C5H10N2O3	L-glutamine
13	C4H8N2O3	L-asparagine
14	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Phase	Method	#Points
POMD	1 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	2 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	3 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	4 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	5 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	6 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	7 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	8 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	9 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	10 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	11 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	12 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1
POMD	13 14	Molar enthalpy of dilution, kJ/mol ; Liquid	Initial molality of solute, mol/kg; Liquid Temperature, K; Liquid Pressure, kPa; Liquid Final molality of solute, mol/kg; Liquid	Liquid	Calvet calorimetry	1

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Study of the interactions of PAMAM-NH2 G4 dendrimer with selected natural amino acids in aqueous solutions

Buczkowski, A.[Adam], Palecz, B.[Bartlomiej]

ABSTRACT