Measurement and modelling of binary (solid + liquid + vapour) equilibria involving lipids and CO2
Freire, T. P. P.[Tamara P.P.], Pedro, A. S.[Andre Sao], Fialho, R.[Rosana], Albuquerque, E. C.[Elaine C.], Bertucco, A.[Alberto], Costa, G. M. N.[Gloria M.N.]
The development of solid lipid nanoparticles (SLN) using supercritical fluid at room temperature is an innovative alternative compared to traditional pharmaceutical methods and the safety and drug efficacy of SLN made using supercritical CO2 is increased. One of the micronization techniques which have provided the best results in the production of SLN is particles from gas-saturated solution (PGSS). The solid liquid vapour coexistence curve of a solid in a compressed gas is of primary importance in assessing the feasibility of PGSS and the selection of appropriate operating conditions. The objectives of this work are to perform experimental measurements using a high pressure differential scanning calorimeter (DSC) to obtain melting properties as a function of composition and develop a simplified approach to model multiphase equilibria of lipids in compressed CO2. The selected lipid was tristearin. Before assessment of triestearin and CO2 phase equilibrium, the performance of this thermodynamic model was evaluated in two other lipids which provided results with high accuracy.
Compounds
#
Formula
Name
1
C57H110O6
glycerol trioctadecanoate
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
Molar enthalpy of transition or fusion, kJ/mol ; Crystal