ABSTRACT

Density (q) and viscosity (g) measurements were carried out for cefepime hydrochloride in water and 0.9 mass % normal saline from (278.15 to 313.15) K. The dependence of density and viscosity on temperature and concentration has been correlated. Apparent molar volumes, standard partial molar volumes, and the viscosity B-coefficient of cefepime hydrochloride were calculated from the experimental measurements. The results are used to establish the nature of solute solute. Solute solvent interactions and structure breaking effect of cefepime hydrochloride have been discussed using the Helper equation and the Jones Dole equation. The relationship between relative changes in viscosity and solute-mixed solvent interaction has been probed.

Compounds

#	Formula	Name
1	H2O	water
2	C19H26Cl2N6O5S2	cefepime dihydrochloride
3	ClNa	sodium chloride

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	8
POMD	1	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	8
POMD	1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	80
POMD	1 2	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	80
POMD	3 1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Solvent: Mass fraction - 3; Liquid	Liquid	Vibrating tube method	72
POMD	3 1 2	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Solvent: Mass fraction - 3; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	72
POMD	3 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Mass fraction - 3; Liquid	Liquid	Vibrating tube method	8
POMD	3 1	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Mass fraction - 3; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	8

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Volumetric and viscometric studies of cefepime hydrochloride in water and normal saline from (278.15 to 313.15) K

Li, Y.[Yu], Li, Y.-h.[Yan-hong], Wang, F.-a.[Fu-an], Ren, B.-z.[Bao-zeng]

ABSTRACT