Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Equilibrium partitioning of drug molecules between aqueous and amino acid ester-based ionic liquids

Jing, J.[Jun], Li, Z.[Zhiyong], Pei, Y.[Yuanchao], Wang, H.[Huiyong], Wang, J.[Jianji]
J. Chem. Thermodyn. 2013, 62, 27-34
ABSTRACT
In this work,a series of novel room temperature ionic liquids (ILs) have been synthesized with cheap, naturally [alpha]-amino acid ester as cations and bis(trifluoromethylsulfonyl)imide as anion. The glass transition temperature and thermal decomposition temperature of these ILs, partition coefficients of some coumarins and purine alkaloids between water and the amino acid ester-based ILs at T = 298.15 K, and Gibbs energy, enthalpy and entropy changes for the transfer of caffeine and 6,7-dihydroxycoumarin from water to [LeuC2][Tf2N] have been determined. It is shown that these ILs are highly effective materials for the extraction of drug compounds like coumarin, 4-hydroxycoumarin, 7-hydroxycoumarin, 3-aminocoumarin, coumarin-3-carboxylic acid, 6,7-dihydroxycoumarin, 6,7-dihydroxy-4-methylcoumarin, caffeine, theobromine, theophylline, inosine, and 2,6-diaminopurine. The partition process is driven by enthalpy term, and partition coefficients of the drug molecules increase with the increase of hydrophobicity of both the drug molecules and the ILs. Furthermore, the possible partition mechanism has been investigated from 13C NMR measurements.
Compounds
# Formula Name
1 C9H6O2 1,2-benzopyrone
2 C9H6O3 7-hydroxy-2H-chromen-2-one
3 C8H10N4O2 caffeine
4 C7H8N4O2 1H-purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-
5 C7H8N4O2 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
6 C10H12N4O5 inosine
7 C5H6N6 2,6-diaminopurine
8 C10H6O4 coumarin-3-carboxylic acid
9 C9H6O3 4-hydroxycoumarin
10 C9H7NO2 3-aminocoumarin
11 C9H6O4 6,7-dihydroxycoumarin
12 C10H8O4 4-methyl-6,7-dihydroxycoumarin
13 C9H16F6N2O6S2 L-leucine methyl ester bis(trifluoromethylsulfonyl)imide
14 C10H18F6N2O6S2 L-leucine ethyl ester bis(trifluoromethylsulfonyl)imide
15 C12H14F6N2O6S2 methyl L-phenylalaninate, comp. with bis(trifluoromethylsulfonyl)imide
16 C11H12F6N2O6S2 glycine benzyl ester bis(trifluoromethylsulfonyl)imide
17 C13H16F6N2O6S2 L-phenylalanine ethyl ester bis(trifluoromethylsulfonyl)imide
18 C11H12F6N2O6S2 L-phenylglycine methyl ester bis(trifluoromethylsulfonyl)imide
19 C15H17F6N3O6S2 L-tryptophan ethyl ester bis(trifluoromethylsulfonyl)imide
20 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 13
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 14
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 15
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 16
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 17
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 18
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 19
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 1
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 1 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 1; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 1
  • 20
  • Amount concentration (molarity), mol/dm3 - 1 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 1; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 1
  • 20
  • Amount concentration (molarity), mol/dm3 - 1 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 1; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 1
  • 20
  • Amount concentration (molarity), mol/dm3 - 1 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 1; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 1
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 1 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 1; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 1
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 1 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 1; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 10
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 10 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 10; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 10
  • 20
  • Amount concentration (molarity), mol/dm3 - 10 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 10; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 10
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 10 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 10; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 10
  • 20
  • Amount concentration (molarity), mol/dm3 - 10 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 10; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 10
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 10 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 10; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 10
  • 20
  • Amount concentration (molarity), mol/dm3 - 10 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 10; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 8
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 8 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 8; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 8
  • 20
  • Amount concentration (molarity), mol/dm3 - 8 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 8; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 8
  • 20
  • Amount concentration (molarity), mol/dm3 - 8 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 8; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 8
  • 20
  • Amount concentration (molarity), mol/dm3 - 8 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 8; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 8
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 8 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 8; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 8
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 8 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 8; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 9
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 9 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 9; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 9
  • 20
  • Amount concentration (molarity), mol/dm3 - 9 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 9; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 9
  • 20
  • Amount concentration (molarity), mol/dm3 - 9 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 9; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 9
  • 20
  • Amount concentration (molarity), mol/dm3 - 9 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 9; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 9
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 9 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 9; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 9
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 9 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 9; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 2
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 2 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 2; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 2
  • 20
  • Amount concentration (molarity), mol/dm3 - 2 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 2; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 2
  • 20
  • Amount concentration (molarity), mol/dm3 - 2 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 2; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 2
  • 20
  • Amount concentration (molarity), mol/dm3 - 2 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 2; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 2
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 2 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 2; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 2
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 2 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 2; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 11
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 11 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 11; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 11
  • 20
  • Amount concentration (molarity), mol/dm3 - 11 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 11; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 11
  • 20
  • Amount concentration (molarity), mol/dm3 - 11 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 11; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 11
  • 20
  • Amount concentration (molarity), mol/dm3 - 11 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 11; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 11
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 11 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 11; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 11
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 11 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 11; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 12
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 12 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 12; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 12
  • 20
  • Amount concentration (molarity), mol/dm3 - 12 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 12; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 12
  • 20
  • Amount concentration (molarity), mol/dm3 - 12 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 12; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 12
  • 20
  • Amount concentration (molarity), mol/dm3 - 12 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 12; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 12
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 12 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 12; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 12
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 12 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 12; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 3
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 3 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 3; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 3
  • 20
  • Amount concentration (molarity), mol/dm3 - 3 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 3; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 3
  • 20
  • Amount concentration (molarity), mol/dm3 - 3 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 3; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 3
  • 20
  • Amount concentration (molarity), mol/dm3 - 3 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 3; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 3
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 3 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 3; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 3
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 3 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 3; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 4
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 4 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 4; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 4
  • 20
  • Amount concentration (molarity), mol/dm3 - 4 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 4; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 4
  • 20
  • Amount concentration (molarity), mol/dm3 - 4 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 4; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 4
  • 20
  • Amount concentration (molarity), mol/dm3 - 4 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 4; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 4
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 4 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 4; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 4
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 4 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 4; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 5
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 5 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 5; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 5
  • 20
  • Amount concentration (molarity), mol/dm3 - 5 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 5; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 5
  • 20
  • Amount concentration (molarity), mol/dm3 - 5 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 5; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 5
  • 20
  • Amount concentration (molarity), mol/dm3 - 5 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 5; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 5
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 5 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 5; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 5
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 5 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 5; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 6
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 6 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 6; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 6
  • 20
  • Amount concentration (molarity), mol/dm3 - 6 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 6; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 6
  • 20
  • Amount concentration (molarity), mol/dm3 - 6 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 6; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 6
  • 20
  • Amount concentration (molarity), mol/dm3 - 6 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 6; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 6
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 6 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 6; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 6
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 6 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 6; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 7
  • 20
  • 13
  • Amount concentration (molarity), mol/dm3 - 7 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 7; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 14
  • 7
  • 20
  • Amount concentration (molarity), mol/dm3 - 7 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 7; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 16
  • 7
  • 20
  • Amount concentration (molarity), mol/dm3 - 7 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 7; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 18
  • 7
  • 20
  • Amount concentration (molarity), mol/dm3 - 7 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 7; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 7
  • 20
  • 15
  • Amount concentration (molarity), mol/dm3 - 7 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 7; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1
  • POMD
  • 7
  • 20
  • 17
  • Amount concentration (molarity), mol/dm3 - 7 ; Liquid mixture 1
  • Amount concentration (molarity), mol/dm3 - 7; Liquid mixture 2
  • Temperature, K; Liquid mixture 1
  • Pressure, kPa; Liquid mixture 1
  • Liquid mixture 1
  • Liquid mixture 2
  • SPECTR
  • 1