ABSTRACT

The densities at T = (288.15, 293.15, 298.15, 303.15, and 308.15) K and sound velocities at T = 298.15 K have been measured for aqueous solutions of trimethylamine-N-oxide, glycine, N-methylglycine (sarcosine), N,N-dimethylglycine, N,N,N-trimethylglycine (betaine). From these data the apparent molar volumes, VU, the apparent molar isentropic compressions, KS,U, and the solvation numbers of solutes have been determined. The concentration dependencies of the calculated quantities and their limiting values are discussed in terms of solute solvent and solute solute interactions. The obtained quantities are compared with the analogous data for urea and its derivatives. These two groups of osmolyties (stabilizers and denaturants of the proteins) reveal clearly different volumetric and compression features.

Compounds

#	Formula	Name
1	C2H5NO2	2-aminoacetic acid
2	C3H7NO2	sarcosine
3	C4H9NO2	(Dimethylamino)acetic acid
4	C5H11NO2	(trimethylammonio)acetate
5	C3H9NO	trimethylamine oxide
6	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	20
POMD	1 6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	1 6	Speed of sound, m/s ; Liquid	Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid	Pulse-echo method	5
POMD	2 6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	2 6	Speed of sound, m/s ; Liquid	Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid	Pulse-echo method	5
POMD	3 6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	3 6	Speed of sound, m/s ; Liquid	Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid	Pulse-echo method	5
POMD	4 6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	4 6	Speed of sound, m/s ; Liquid	Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid	Pulse-echo method	5
POMD	5 6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 5; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	5 6	Speed of sound, m/s ; Liquid	Molality, mol/kg - 5; Liquid	Pressure, kPa; Liquid Temperature, K; Liquid	Liquid	Pulse-echo method	5

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

The hydration of the protein stabilizing agents: Trimethylamine-N-oxide, glycine and its N-methylderivatives The volumetric and compressibility studies

Krakowiak, J.[Joanna], Wawer, J.[Jaroslaw], Panuszko, A.[Aneta]

ABSTRACT