ABSTRACT

Density and viscosity measurements are reported for aqueous solutions of the drugs like Metformin hydrochloride (MH), Ranitidine hydrochloride (RH) and Tramadol hydrochloride (TH) at different temperatures T = (288.15, 298.15, and 308.15) K within the concentration range (0 to 0.15) mol kg-1. The density and viscosity data are used to obtain apparent molar volume of solute and relative viscosity of aqueous solutions at different temperatures. The limiting apparent molar volume of solute, limiting apparent molar expansivity, thermal expansion coefficient, hydration number, Jones-Dole equation viscosity A and B coefficients, experimental slope at different temperatures, and temperature coefficient of B i.e. (dB/dT) at T = 298.15 K were also obtained. The results obtained have been interpreted in terms of solute-solvent and solute-solute interactions and structure making/breaking ability of solute in the aqueous solution.

Compounds

#	Formula	Name
1	C4H12ClN5	N,N-dimethylimidodicarbonimidic diamide hydrochloride
2	H2O	water
3	C13H23ClN4O3S	ranitidine hydrochloride
4	C16H26ClNO2	tramadol hydrochloride

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Pycnometric method	35
POMD	1 2	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	35
POMD	2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Pycnometric method	36
POMD	2 3	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	36
POMD	2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Pycnometric method	38
POMD	2 4	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	38

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Volumetric and viscometric studies of some drugs in aqueous solutions at different temperatures

Dhondge, S. S.[Sudhakar S.], Zodape, S. P.[Sangesh P.], Parwate, D. V.[Dilip V.]

ABSTRACT