ABSTRACT

Using a laser monitoring observation technique, the solubilities of paroxetine hydrochloride hemi-hydrate in (water + acetone) were determined by the synthetic method from (294.45 to 323.20) K, respectively. Results of these measurements were correlated by the three variants of the combined nearly ideal binary solvent/Redlich Kister (CNIBS/R K) model. For the seven group data studied, three variants of the (CNIBS/R K) equation were found to provide accurate mathematical representations of the experimental data and variant 2 is the best of the three variants.

Compounds

#	Formula	Name
1	H2O	water
2	C3H6O	acetone
3	C7H6O2	benzoic acid
4	C38H44Cl2F2N2O7	paroxetine hydrochloride hemihydrate

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	4	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	4	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	3 1	Solid-liquid equilibrium temperature, K ; Liquid	Mole fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 3	VISOBS	17
POMD	2 4	Mole fraction - 4 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	laser monitoring observation	7
POMD	1 4	Mole fraction - 4 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	laser monitoring observation	7
POMD	2 1 4	Mole fraction - 4 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 4	laser monitoring observation	77

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Solubility of paroxetine hydrochloride hemi-hydrate in (water + acetone)

Ren, G.-B.[Guo-Bin], Wang, J.-K.[Jing-Kang], Li, G.[Guizhi]

ABSTRACT