Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Solubility and density of the disodium salt hemiheptahydrate of ceftriaxone in (acetone + water) at T=(298.15,308.15, and 318.15) K

Dong, H.[Hong], Fu, R.[Ranran], Yan, W.[Weidong], Zhu, M.
J. Chem. Thermodyn. 2004, 36, 2, 155-159
ABSTRACT
The solubility of disodium salt hemiheptahydrate of ceftriaxone in different concentrations of acetone in water at T=(298.15,308.15, and 318.15) K was measured by using gravimetrical method. The density of the saturated solution was also determined with the help of a digital densimeter (Anton Paar, model DMA 45) at corresponding temperatures. The solubility of disodium salt hemiheptahydrate of ceftriaxone increases with increasing temperature, but decreases with increasing concentration of acetone in the solution. The experimental data were correlated with equation (4). The correlation is satisfactory with the average absolute deviation of 1.67 g ? kg-1 mixed solvents.
Compounds
# Formula Name
1 C18H16N8Na2O7S3 disodium ceftriaxone
2 H2O water
3 C3H6O acetone
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • 2
  • 1
  • Mass ratio of solute to solvent - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • OTHER
  • 24
  • POMD
  • 3
  • 2
  • 1
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • VIBTUB:UFactor:64
  • 24