Solubility measurement of solid solute components in supercritical carbon dioxide (SC-CO2) provides essential information for forming pharmaceutical particles of smaller size with a desired size distribution, so as to achieve a better dissolution rate. In this study, for the first time, solubility of amiodarone hydrochloride (AMH) in SC-CO2 was determined using a static method at pressures and temperatures ranging within (12 to 30) MPa and (313.2 to 343.2) K, respectively. Under the applied conditions, molar solubilities were obtained in the range of 2.510 x 10^-5 to 1.012 x 10^-3. For correlating the drug solubility in SC-CO2, three of the most widely applied groups of models, namely semi-empirical density-based approaches, equations of state (EoSs), and regular solution models, were used. Statistical analysis of the results showed the superiority of the Peng-Robinson's model over other models for estimating the solubility of AMH based on experimental data.
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
2
1
Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
Temperature, K; Fluid (supercritical or subcritical phases)
Pressure, kPa; Fluid (supercritical or subcritical phases)