The solubility of ethenzamide in methanol, ethanol, 1-propanol, isobutanol, ethyl acetate and acetonitrile was determined via the gravimetric method in the temperature range from 288.15 K to 323.15 K at atmospheric pressure. Five thermodynamic models were employed to correlate the experimental solubility data. The correlated results were analyzed and compared with the experimental results. It was found that all the thermodynamic models give satisfactory correlation results, in which the modified Apelblat model shows the best fitting result. In addition, the molecular modeling studies were carried out to give the explanation for the sequence of solubility in various solvents. The dissolution enthalpy and entropy of ethenzamide were obtained by using the Van't Hoff equation. Furthermore, the mixing thermodynamic properties of ethenzamide, including the mixing Gibbs energy, the mixing enthalpy and entropy, as well as the infinite-dilution activity coefficient and the infinitesimal concentration reduced excess enthalpy, were also obtained by using the Wilson model and the experimental solubility values.
Compounds
#
Formula
Name
1
C9H11NO2
Ethenzamide
2
CH4O
methanol
3
C2H6O
ethanol
4
C3H8O
propan-1-ol
5
C4H10O
2-methyl-1-propanol
6
C4H8O2
ethyl acetate
7
C2H3N
acetonitrile
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
Normal melting temperature, K ; Crystal
Crystal
Liquid
Air at 1 atmosphere
DTA
1
POMD
1
Molar enthalpy of transition or fusion, kJ/mol ; Crystal