Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Aqueous solubility of acetaminophen in the presence of 1-hexyl-3- methyl imidazolium bromide, ionic liquid as co-solvent

Mehrdad, A.[Abbas], Miri, A. H.[Amir Hossein]
Fluid Phase Equilib. 2016, 425, 51-56
ABSTRACT
Aqueous solubility of acetaminophen in the presence of 1-hexyl-3-methyl imidazolium bromide, ionic liquid as co-solvent was investigated at different temperatures and mass fraction of ionic liquid. The obtained results reveal that the solubility of acetaminophen was increased by increasing temperature and concentration of ionic liquid. Thermodynamic functions of dissolution, mixing and transfer process were calculated by Van't Hoff equation. The experimental solubility of acetaminophen was correlated with the Wilson and NRTL models as activity coefficient model. The obtained average relative deviations indicate that the experimental solubility of acetaminophen in aqueous ionic liquid solution has a good correlation with the Wilson and NRTL models.
Compounds
# Formula Name
1 C8H9NO2 N-acetyl-p-aminophenol
2 C10H19BrN2 3-hexyl-1-methyl-1H-imidazolium bromide
3 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 3
  • 2
  • Mass fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • gravimetric
  • 36
  • POMD
  • 1
  • 3
  • 2
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • gravimetric
  • 36
  • POMD
  • 1
  • 3
  • Mass fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • gravimetric
  • 6
  • POMD
  • 1
  • 3
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • gravimetric
  • 6