ABSTRACT

The solubility of flunixin meglumine (FM) in six pure solvents and binary solvents of ethanol + isopropanol was measured over the temperature ranged from 283.15 K to 328.15 K by using a static gravimetric method. Itis positively correlated with temperature and negatively correlated with the molar fraction of isopropanol. The modified Apelblat equation was used to correlate the experimental solubility in pure solvents. Dissolution properties based on the modified Apelblat equation were calculated and discussed. The solubility in binary solvents at various temperatures was well correlated by the nearly ideal binary solvent (NIBS)/Redlich-Kister model. In addition, in order to correlate the solubility to both the composition and temperature in mixed solvents, a new model related to dielectric constant was proposed.

Compounds

#	Formula	Name
1	C21H28F3N3O7	(2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentaol; 2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
2	H2O	water
3	CH4O	methanol
4	C2H6O	ethanol
5	C3H8O	propan-2-ol
6	C3H6O	acetone
7	C2H3N	acetonitrile

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	1	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	7 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	10
POMD	4 5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 5; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	110

Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Measurement and correlation of solubility and dissolution properties of flunixin meglumine in pure and binary solvents

Qin, Y.[Yujia], Wang, H.[Haisheng], Yang, P.[Peng], Du, S.[Shichao], Huang, C.[Cui], Du, Y.[Yanni], Wu, S.[Songgu], Gong, J.[Junbo], Yin, Q.[Qiuxiang]

ABSTRACT