The solubility of Cefaclor in water, methanol, ethanol and acetone was studied under atmospheric pressure in the 278.15 313.15 K temperature range using a dynamic laser method. The modified Apelblat model and a polynomial equation were used to model the experimental data, and both models provided good fits (R2 greater than 0.99). The changes in the standard enthalpy, entropy and Gibbs free energy upon dissolution of Cefaclor were calculated to obtain thermodynamics data related to Cefaclor crystallisation. The results show that the dissolution process was endothermic and nonspontaneous, and that the main contributing force was the enthalpy in methanol, ethanol and acetone solvents.
Compounds
#
Formula
Name
1
H2O
water
2
CH4O
methanol
3
C2H6O
ethanol
4
C3H6O
acetone
5
C15H14ClN3O4S
cefaclor
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.