Solubility of (+)-Catechin in Water and Water-Ethanol Mixtures within the Temperature Range 277.6 to 331.2 K: Fundamental Data to Design Polyphenol Extraction Processes
(+)-Catechin is a fundamental polyphenol commonly found in nature. Its aqueous solubility is a key parameter for designing and optimizing extraction processes used to obtain phenolic bioactive compounds from plant material. In this work, the solubility of (+)-catechin in water and water-ethanol mixtures was measured spectrophotometrically using a novel shake-flask method (based on a Carousel 12 PlusTM Reaction Station) within the temperature range 277.6 331.2 K. A HPLC-DAD system was also used to confirm the solubility measurements. The novel method was previously validated by determining the solubility of benzoic acid in water at temperatures ranging from 278.5 to 340.9 K and comparing to literature data. Results showed that the aqueous solubility of (+)-catechin increases with temperature and ethanol concentration, a trend that was well correlated using the so-called Apelblat equation. This behavior was supported by the thermodynamic properties of solution (DGsol, DHsol, and DSsol), whose values indicated that the processes of dissolving (+)-catechin hydrate in water and water ethanol mixtures were endothermic and entropy-controlled.
Compounds
#
Formula
Name
1
C15H14O6
(+)-catechin
2
C7H6O2
benzoic acid
3
C2H6O
ethanol
4
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.