ABSTRACT

The solubility data of sulbactam in seven pure solvents and a binary solvent system were determined from 278.15 K to 308.15 K using a gravimetrical method under atmospheric pressure. Since sulbactam will decompose before melting, the group contribution method was used to estimate the melting point and the enthalpy of fusion of sulbactam. The measured data in pure solvents were correlated with the modified Apelblat equation, the Wilson model and the NRTL model. And for the binary solvent system, the CNIBS/R-K model and Jouyban-Acree model were used to correlate the solubility data. Moreover, the van't Hoff equation was adopted to calculate the enthalpy, entropy and Gibbs energy change during the dissolution process.

Compounds

#	Formula	Name
1	C8H11NO5S	(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
2	C3H6O	acetone
3	CH4O	methanol
4	C2H6O	ethanol
5	C3H8O	propan-1-ol
6	C3H8O	propan-2-ol
7	C4H10O	butan-1-ol
8	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	8 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	7 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	7
POMD	3 8 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	56

Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Solid-liquid equilibrium of sulbactam in pure solvents and binary solvent mixtures

Wang, H.[Huihui], Wang, Y.[Yongli], Wang, G.[Guan], Zhang, J.[Jie], Hao, H.[Hongxun], Yin, Q.[Qiuxiang]

ABSTRACT