In this work, a new setup was designed in order to measure solubility of several solids in a sub or supercritical {CO2 - solvent} mixture. The equipment is suitable to operate at temperatures ranging from (293 to 333) K and pressures up to 20 MPa. An analytical method was used, based on a variable-volume cell with sampling of fluid phase for HPLC analysis. Solubility of naproxen (NPX) and nicotinamide (NCTA) and their mixture in {acetone + supercritical CO2} systems were measured at two temperatures (298.15 and 310.65 K) and at 10 MPa over all range of CO2 compositions. CO2 acts as an anti-solvent for both solutes. For a quaternary mixture with an initial NPX:NCTA molar ratio of 2:1, the addition of CO2 induced the formation of cocrystal with a 2 :1 stoichiometry. The solubility of NPX and NCTA decreased compared to the ternary systems. The solubility of NPX and NCTA increased with temperature.
Compounds
#
Formula
Name
1
C6H6N2O
3-pyridinecarboxamide
2
CO2
carbon dioxide
3
C3H6O
acetone
4
C14H14O3
(S)-(+)-naproxen
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.