The solubility of valnemulin hydrogen tartrate in five pure solvents was determined in temperature range of 278.15 K to 333.15 K by using a static analytical method. Five thermodynamic models were used to correlate the experimental solubility data. The correlated results were analyzed and compared with experimental results. It was found that the correlated results were in good agreement with the experimental results. By using the Van't Hoff equation, the dissolution enthalpy and entropy of valnemulin hydrogen tartrate in different solvents were calculated. The mixing thermodynamic properties of valnemulin hydrogen tartrate, including the mixing Gibbs energy, the mixing enthalpy and entropy, as well as the infinite-dilution activity coefficient and the excess enthalpy, were determined by using the Wilson model and the experimental solubility data.
Compounds
#
Formula
Name
1
H2O
water
2
C2H6O
ethanol
3
C3H8O
propan-2-ol
4
C4H10O
butan-1-ol
5
C3H6O
acetone
6
C35H58N2O11S
valnemulin hydrogen tartrate
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
6
Normal melting temperature, K ; Crystal
Crystal
Liquid
Air at 1 atmosphere
DTA
1
POMD
6
Molar enthalpy of transition or fusion, kJ/mol ; Crystal