Soly. is an important physiochem. property of pharmaceutical compds., and cocrystn. is one method used to improve the soly. of drugs. Carbamazepine is a drug from class II, according to the biopharmaceutical classification system, and it forms a cocrystal with nicotinamide. Carbamazepine cocrystd. with nicotinamide was synthesized using the solvent evapn. approach, and its characteristics were detd. using differential scanning calorimetry and powder X-ray diffractometry. The soly. of various solid phases in ethanol + water mixts. was investigated at different temps. using the shake-flask method, and the resulting ppts. were characterized. The soly. of carbamazepine was increased with the addn. of ethanol up to a mass fraction of 0.8. Nevertheless, max. soly. of NIC is obsd. in neat solvent (water). While the soly. of a cocrystal depends on the concn. of the coformer and its stability in the soln.
Compounds
#
Formula
Name
1
C6H6N2O
3-pyridinecarboxamide
2
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.