ABSTRACT

The solubility of cefoperazone in four pure solvents and a binary solvent mixture (acetone + water) were experimentally determined from 278.15 to 313.15 K by using a gravimetric method. The solubility data in pure solvents (acetone, 2-propanol, ethanol and water) were well correlated by using the modified Apelblat equation. The CNIBS/R-K model and Jouyban-Acree model were used to correlate the solubility data in binary mixture. Furthermore, the enthalpy, entropy and Gibbs energy change of dissolution of cefoperazone in different solvents were also calculated by using the van't Hoff equation.

Compounds

#	Formula	Name
1	C25H26N9O8S2	(6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
2	C3H6O	acetone
3	C2H6O	ethanol
4	C3H8O	propan-2-ol
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric Method	8
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric Method	8
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric Method	8
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric Method	8
POMD	2 5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Mole fraction - 5; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Gravimetric	88

Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Determination and correlation of cefoperazone solubility in different pure solvents and binary mixture

Wang, G.[Guan], Wang, Y.[Yongli], Hu, X.[Xiaowei], Ma, Y.[Youguang], Hao, H.[Hongxun]

ABSTRACT