In the present work, the solubility of spironolactone in supercritical carbon dioxide was measured using a static technique coupled with a gravimetric method. The solubility of this model drug was measured in the ranges of 308 to 338 K and 160 to 400 bar, respectively. The results showed that the solubility of spironolactone was in the range of 6.25 x 10-5 to 5.01 x 10-3 based on the mole fraction at the studied temperatures and pressures. In addition, the measured solubility data were correlated using semi-empirical density based correlations (Mendez Santiago-Teja (MST) and Kumar and Johnston (K-J)) and an equation of state (Peng-Robinson (PR)). Obtained results showed better capability of the semi-empirical correlations compared with the PR-EoS for correlating the solubility of spironolactone at the studied temperatures and pressures.
Compounds
#
Formula
Name
1
C24H32O4S
spironolactone
2
CO2
carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
2
Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
Temperature, K; Fluid (supercritical or subcritical phases)
Pressure, kPa; Fluid (supercritical or subcritical phases)