The purpose of this study is to measure the solubilities of poorly water-soluble drugs, and to enhance their solubilities by adding co-solvents. Etodolac, a cyclooxygenase-2 (cox-2) inhibitor in non-steroid anti-inflammatory drugs (NSAIDs), was selected as a model pharmaceutical compound. The solubilities of etodolac were determined at 298.15 K in mixtures of water and the following six cyclodextrins(CDs) using high-performance liquid chromatography: alpha-CD, beta-CD, gamma-CD, 2-hydroxypropyl-beta-CD, 2-hydroxyethyl-beta-CD, and methyl-beta-CD. With the exception of gamma-CD, the experimental solubility datawere correlated using a modified Chrastil model. Additionally, the solubilization power of each correlated cosolvent-solute system was evaluated using a log-linear model. Finally, the stability constantswere determined using the Takeru Higuchi-Connors solubility method.
Compounds
#
Formula
Name
1
C36H60O30
.alpha.-cyclodextrin
2
C42H70O35
.beta.-cyclodextrin
3
C48H80O40
.gamma.-cyclodextrin
4
C17H21NO3
etodolac
5
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.