Meropenem exists in the solid state as trihydrate and methylate. In the present work, the solubility data of meropenem in mixed methanol water solvent ranging from 273.15 K to 288.15 K were measured and pseudopolymorphic transitions of meropenem were first observed. The transition points were determined at various temperatures. The corresponding water/methanol activities at transition points were calculated using Wilson equation, and correlated by van't Hoff equation. The results show that the ratio of water activity to methanol activity plays a crucial role in determining the thermodynamic stability of trihydrate and methylate of meropenem at a specific temperature. The result can be extended to the application of other pseudopolymorphic systems.
Compounds
#
Formula
Name
1
C17H31N3O8S
meropenem trihydrate
2
C19H33N3O7S
meropenem dimethylate
3
CH4O
methanol
4
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.