In this study the phase equilibrium behavior of the binary system CO2 (1) + medroxyprogesterone acetate (2) was determined. The static synthetic method, using a variable-volume view cell, was employed to obtain the experimental data in the temperature range of 303.15 343.15 K and pressures up to about 22 MPa. The mole fraction of medroxyprogesterone acetate varied in the range from 4 * 10-5 to 9 * 10-5. For this system (fluid + solid) and (fluid + fluid + solid) transitions were observed. The phase equilibrium data obtained in this work were modeled using the Peng Robinson equation of state for describing fluid mixtures, and an expression for the fugacity of pure solid medroxyprogesterone acetate (MPgAc) for representing the solid phase. The thermodynamic model was able to satisfactorily describe the phase behavior of the system investigated.
Compounds
#
Formula
Name
1
C24H34O4
17.alpha.-acetoxy-6.alpha.-methylprogesterone
2
CO2
carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
2
Mole fraction - 1 ; Fluid (supercritical or subcritical phases)
Temperature, K; Fluid (supercritical or subcritical phases)
Pressure, kPa; Fluid (supercritical or subcritical phases)