ABSTRACT

By using a laser monitoring observation technique, the solubilities of lansoprazole in ten pure solvents as well as in a binary solvent mixture (isopropyl alcohol) were measured in the temperature ranging from 283.15 to 318.15 K. The experimental data were fitted using the modified Apelblat equation and two variants of the combined nearly ideal binary solvent/Redlich Kister (CNIBS/R K) model. The models were proven to give good representations of the experimental data. Computational results showed that variant 2 was superior to the variant 1 after comparison between the two variants of CNIBS/R-K model. The solubility enthalpy and entropy of lansoprazole in all pure solvents and the mixed solvent system were calculated using van't Hoff equation. The dissolving process was endothermic and entropy-driving.

Compounds

#	Formula	Name
1	C16H14F3N3O2S	lansoprazole
2	C3H6O	acetone
3	C4H8O	butanone
4	C6H12O	4-methylpentan-2-one
5	C4H8O2	ethyl acetate
6	C6H12O2	butyl ethanoate
7	C6H12O2	2-methylpropyl ethanoate
8	C3H8O	propan-1-ol
9	C3H8O	propan-2-ol
10	C4H10O	butan-1-ol
11	C5H12O	pentan-1-ol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	6
POMD	3 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	4 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	5 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	6 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	7 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	8 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	9 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	8
POMD	10 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	11 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	7
POMD	9 2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 2; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	laser monitoring	54

Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Solubility of lansoprazole in different solvents

Hong, m.[Minghuang], Xu, L.[Lehui], Ren, G.[Guobin], Chen, J.[Jinyao], Qi, M.[Minghui]

ABSTRACT