The solubility of levofloxacin in six solvents including ethanol, 1-propanol, 2-propanol, 1-butanol, acetic acid and ethyl acetate in the temperature range of 288.15 to 328.15 K at atmospheric pressure was measured by a balance method. It is indicated that the solubility data of levofloxacin in selected solvents increase with increasing temperature. The experimental solubilities were correlated by the modified Apelblat equation which fits well with the experimental data. Further the molecular modeling studies indicate that the higher solubility of levofloxacin in acetic acid is due to the stronger hydrogen bonds between the solute and solvent molecules. The dissolution enthalpy, dissolution entropy and the molar Gibbs energy were predicted. Finally, the solubility data were correlated using two local composition models of NRTL 1 and UNIQUAC.
Compounds
#
Formula
Name
1
C18H20FN3O4
levofloxacin
2
C2H6O
ethanol
3
C3H8O
propan-1-ol
4
C3H8O
propan-2-ol
5
C4H10O
butan-1-ol
6
C2H4O2
acetic acid
7
C4H8O2
ethyl acetate
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.