Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Determination of the solubility, dissolution enthalpy and entropy of icariin in water, ethanol, and methanol

Wang, N.[Na], Fu, Q.[Qiang], Yang, G.[Guangde]
Fluid Phase Equilib. 2012, 324, 41-43
ABSTRACT
The solubility of icariin in water, ethanol, and methanol solutions was measured by UV spectrophotometry from 288.2 K to 328.2 K. The solubility of icariin in the three solvents increased with temperature. Solubility data correlated with a modified Apelblat equation. The enthalpy and entropy of dissolution of icariin were determined using van't Hoff plots. The polarity indices and the surface tension of solvents affect the solubility behaviour.
Compounds
# Formula Name
1 C33H40O15 icariin
2 C2H6O ethanol
3 CH4O methanol
4 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 4
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • UV spectroscopy
  • 9
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • UV spectroscopy
  • 9
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • UV spectroscopy
  • 9