By using the van't Hoff and Gibbs equations the thermodynamic functions Gibbs energy, enthalpy, and entropy of solution and of mixing of naproxen (NAP) in some ethyl acetate + ethanol mixtures were evaluated from solubility data determined at several temperatures. By means of enthalpy-entropy compensation analysis, a non linear delta_H vs. delta_G compensation plot with negative and positive slopes was obtained if all the composition intervals are considered. Finally, the Jouyban-Acree model has been applied to correlate the drug solubilities as well as the respective thermodynamic quantities of solution in these solvent mixtures.
Compounds
#
Formula
Name
1
C14H14O3
(S)-(+)-naproxen
2
C4H8O2
ethyl acetate
3
C2H6O
ethanol
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.