ABSTRACT

The solubility of Deflazacort in four solvents, acetone, ethyl acetate, ethanol and 2-propanol, was measured at temperatures ranging from 293.15 K to 348.15 K at atmospheric pressure using Laser Monitoring Technique. The solubility data were correlated by the modified Apelblat model. Then the dissolution enthalpy and entropy of Deflazacort were predicted from the solubility data using van't Hoff equation. In this study, it should be concluded that the viscosity and surface tension of solvents affect the solubility behavior, dissolution enthalpy and entropy of Deflazacort in different solvents.

Compounds

#	Formula	Name
1	C3H6O	acetone
2	C25H31NO6	deflazacort
3	C4H8O2	ethyl acetate
4	C2H6O	ethanol
5	C3H8O	propan-2-ol

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	Derived from van't Hoff Equation	1
POMD	1 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Synthetic	7
POMD	3 2	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	Derived from van't Hoff Equation	1
POMD	3 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Synthetic	11
POMD	4 2	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	Derived from van't Hoff Equation	1
POMD	4 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Synthetic	11
POMD	5 2	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 2	Derived from van't Hoff Equation	1
POMD	5 2	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	Synthetic	12

Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Determination of the solubility, dissolution enthalpy and entropy of Deflazacort in different solvents

Wang, P.[Peng], Wang, J.[Jingkang], Gong, J.[Junbo], Meijing, Z.[Zhang]

ABSTRACT