The solubilities of cholesterol and desmosterol in binary solvent mixtures of n-hexane + ethanol at temperatures of 293.2 323.2K were determined by a static equilibrium method. The solubilities increase with temperature and go through a maximum at a specific solvent composition. The fusion enthalpy fusH and the melting point Tm, determined by differential scanning calorimeter (DSC), are 28.5 kJ/mol, 421.7K for cholesterol and 15.9 kJ/mol, 388.2K for desmosterol, respectively. The solubilities of cholesterol and desmosterol in pure n-hexane or ethanol follow a linear Van t Hoff relation with temperature. Activity models, such as Wilson, NRTL and UNIQUAC models were used to correlate and predict the solubilities of cholesterol and desmosterol in n-hexane + ethanol mixed solvents. The interaction parameters were expressed as a function of temperature. (C) 2009 Elsevier B.V. All rights reserved.
Compounds
#
Formula
Name
1
C27H46O
.DELTA.5-cholesten-3.beta.-ol
2
C27H44O
desmosterol
3
C2H6O
ethanol
4
C6H14
hexane
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.
Type
Compound-#
Property
Variable
Constraint
Phase
Method
#Points
POMD
1
Molar enthalpy of transition or fusion, kJ/mol ; Crystal