Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Measurement and correlation of solubility of artemisinin in supercritical carbon dioxide

Gong, X.-Y.[Xiao-Yan], Cao, X.-J.[Xue-Jun]
Fluid Phase Equilib. 2009, 284, 1, 26-30
ABSTRACT
Artemisinin is an effective antimalarial drug isolated from the herbal medicine Artemisia annua L. Supercritical fluid extraction is an environment-friendlymethod for the extraction of artemisinin. In thiswork, the solubility of artemisinin in supercritical carbon dioxide was determined by static method at three temperatures of 313K, 323 K, 333K and pressures from 11 to 31MPa. The range of experimental solubility datawas from0.498*10-3 to 2.915*10-3 mol/mol under the above-mentioned conditions.Two densitybased models (Chrastil and Mendez Santiago Teja models) were selected to correlate the experimental data of this work, and the average absolute relative deviation (AARD) was 8.32% and 8.33%, respectively. The correlation results showed good agreement with the experimental data.
Compounds
# Formula Name
1 C15H22O5 artemisinin
2 CO2 carbon dioxide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Gas
  • Temperature, K; Gas
  • Pressure, kPa; Gas
  • Gas
  • Crystal 1 - 1
  • static method
  • 27