The solid solubilities of three active pharmaceutical ingredients (APIs) of antipyrine, 4-aminoantipyrine and 4-dimethylaminoantipyrine in supercritical carbon dioxidewere measured by a semi-flowapparatus. The experiments were taken at 308.2, 318.2 and 328.2 K. The pressure range was from 10 to 22MPa. These experimental results were correlated by the semi-empirical models of Mendez Santiago Teja and Chrastil. A solution model was also employed to fit the measured data. The average absolute relative deviation in solid solubility from semi-empirical modelswas 4 6%, and that from the solution modelwas 5 8%. The measured data satisfied the self-consistency test, and the parameters in the semi-empirical models are feasible for data extrapolation.
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.