By using the Gibbs and van ft Hoff equations the thermodynamic functions Gibbs free energy, enthalpy, and entropy of solution, mixing and solvation of ibuprofen (IBP) and naproxen (NAP), in some ethanol (EtOH) + propylene glycol (PG) cosolvent mixtures, were evaluated from both drugs solubility values determined at several temperatures. The drugs solubility was greater in pure EtOH and lower in PG in almost all the cases studied. The solvation of these drugswas almost constant in all the cosolvent mixtures tested. By means of enthalpy.entropy compensation analysis, non-linear H.soln vs. G.soln compensation plots with positive and negative slopes were obtained for IBP and NAP, respectively. These behaviors are probably due to the increase in solvation of IBP by EtOH molecules; whereas in the NAP case, it is probably due to the solvent-structure loosing.
Compounds
#
Formula
Name
1
C13H18O2
ibuprofen
2
C14H14O3
(S)-(+)-naproxen
3
C2H6O
ethanol
4
C3H8O2
1,2-propanediol
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.