Thermodynamics Research Center / ThermoML | Fluid Phase Equilibria

Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures

Huang, Z.[Zhen], Chiew, Y. C.[Yee C.], Lu, W. D.[Wei D.], Kawi, S.[Sibudjing]
Fluid Phase Equilib. 2005, 237, 1-2, 9-15
ABSTRACT
The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol% methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng Robinson equation of state model with an AARD ranging from 14 to 23%.
Compounds
# Formula Name
1 CO2 carbon dioxide
2 C9H8O4 2-acetoxybenzoic acid
3 CH4O methanol
4 C2H6O ethanol
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 2
  • 3
  • 1
  • Mole fraction - 2 ; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Mole fraction - 3; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • dynamic saturation method
  • 10
  • POMD
  • 2
  • 4
  • 1
  • Mole fraction - 2 ; Fluid (supercritical or subcritical phases)
  • Pressure, kPa; Fluid (supercritical or subcritical phases)
  • Temperature, K; Fluid (supercritical or subcritical phases)
  • Mole fraction - 4; Fluid (supercritical or subcritical phases)
  • Fluid (supercritical or subcritical phases)
  • Crystal - 2
  • dynamic saturation method
  • 10