Densities () () of (0.01 to 0.07) mol*kg -1 mol*kg-1 L-Glutamic acid HCl (L-HCl) drug in water, and in aqueous NaCl and KCl (0.5 and 1.0) mol*kg -1 mol*kg-1 solutions have been reported as a function of temperature at T=(298.15,303.15,308.15 T=(298.15,303.15,308.15 , and 313.15) K and atmospheric pressure. The accurate density () () values are used to estimate the various parameters such as the apparent molar volume (V 2,f ) (V2,f) , the partial molar volume (V 8 2 ) (V28) , the isobaric thermal expansion coefficient (a 2 ) (a2) , the partial molar expansion (E 8 2 ) (E28) , and Hepler s constant (? 2 V 8 2 /T 2 ) P (2V28/T2)P . The Cosphere overlap model is used to understand the solute solvent interactions in a ternary mixture (L-HCl drug + NaCl or KCl + water). Hepler s constant (? 2 V 8 2 /T 2 ) P (2V28/T2)P is utilized to interpret the structure-making or -breaking ability of L-HCl drug in aqueous NaCl and KCl solutions, and the results are inferred that L-HCl drug acts as a structure maker, i.e., kosmotrope in aqueous NaCl solutions and performs as a structure breaker, i.e., chaotrope in aqueous KCl solutions.
Compounds
#
Formula
Name
1
C5H10ClNO4
L-glutamic acid hydrochloride
2
ClNa
sodium chloride
3
ClK
potassium chloride
4
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.