2
0
2010
jin
wan
1
journal
Original
Jing, D.[Dingding]
Wang, J.[Jingkang]
Wang, Y.[Yongli]
J. Chem. Eng. Data
2010
2020-09-29
Solubility of Penicillin Sulfoxide in Different Solvents
The solubilities of penicillin sulfoxide in ethyl acetate, 4-methyl-2-pentanone, butyl acetate, and toluene from (273.15 to 332.75) K were measured with the mole fraction by a gravimetric method The solubilities in these solvents are temperature dependent. The results show that the solubility of penicillin sulfoxide in toluene is very low, so toluene is considered as one of the best solvents and used in industry. According to the results, we can see that the solubilities of penicillin sulfoxide in ethyl acetate, 4-methyl-2-pentanone, butyl acetate, and toluene can be correlated well with a semiempirical equation.
10.1021/je900326e
1
55
508-509
1
InChI=1S/C16H18N2O5S/c1-16(2)12(15(21)22)18-13(20)11(14(18)24(16)23)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-,24-/m1/s1
FCZNNHHXCFARDY-RRJWCGLDSA-N
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, 4-oxide, stereoisomer
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, 4-oxide, (4.beta.)-
benzylpenicillin S-sulfoxide
C16H18N2O5S
1
Commercial source
1
Crystallization from melt
2
99.2
3
HPLC
2
InChI=1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
XEKOWRVHYACXOJ-UHFFFAOYSA-N
ethyl acetate
ethyl ethanoate
C4H8O2
1
Commercial source
1
99.5
3
Stated by supplier
2
None used
3
InChI=1S/C6H12O/c1-5(2)4-6(3)7/h5H,4H2,1-3H3
NTIZESTWPVYFNL-UHFFFAOYSA-N
4-methylpentan-2-one
4-methyl-2-pentanone
isobutyl methyl ketone
isopropyl acetone
methyl isobutyl ketone
C6H12O
1
Commercial source
1
99.5
3
Stated by supplier
2
None used
4
InChI=1S/C6H12O2/c1-3-4-5-8-6(2)7/h3-5H2,1-2H3
DKPFZGUDAPQIHT-UHFFFAOYSA-N
butyl ethanoate
acetic acid, butyl ester
butyl acetate
ethanoic acid, butyl ester
n-butyl acetate
C6H12O2
1
Commercial source
1
99.5
3
Stated by supplier
2
None used
5
InChI=1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3
YXFVVABEGXRONW-UHFFFAOYSA-N
toluene
methylbenzene
C7H8
1
Commercial source
1
99.5
3
Stated by supplier
2
None used
1
1
1
Principal objective of the work
RRP
TRC
1/22/2010
1
Normal melting temperature, K
DTA
Crystal
Direct value, X
1
Data file compiler
Propagation of evaluated standard uncertainties
95
Crystal
Liquid
Air at 1 atmosphere
1
437.15
4
1
1
2
2
1
1
1
Principal objective of the work
RRP
TRC
1/22/2010
1
Mole fraction
Titration method
1
Liquid
Direct value, X
1
Data file compiler
Propagation of evaluated standard uncertainties
95
Liquid
Crystal
1
1
Pressure, kPa
Liquid
101
3
1
Temperature, K
Liquid
1
273.15
5
1
0.0021072
5
1
8.62e-05
1
278.15
5
1
0.0022178
5
1
9.07e-05
1
283.25
5
1
0.0022717
5
1
9.29e-05
1
288.15
5
1
0.0023313
5
1
9.53e-05
1
292.75
5
1
0.0025638
5
1
0.0001048
1
298.55
5
1
0.0027962
5
1
0.0001143
1
303.15
5
1
0.0031588
5
1
0.0001291
1
307.45
5
1
0.0033768
5
1
0.0001381
1
312.85
5
1
0.0038323
5
1
0.0001567
1
317.65
5
1
0.0044004
5
1
0.0001799
1
321.25
5
1
0.0048587
5
1
0.0001987
3
3
1
1
1
Principal objective of the work
RRP
TRC
1/22/2010
1
Mole fraction
Titration method
1
Liquid
Direct value, X
1
Data file compiler
Propagation of evaluated standard uncertainties
95
Liquid
Crystal
1
1
Pressure, kPa
Liquid
101
3
1
Temperature, K
Liquid
1
273.15
5
1
0.0016207
5
1
6.59e-05
1
278.15
5
1
0.0017321
5
1
7.05e-05
1
283.15
5
1
0.0018004
5
1
7.32e-05
1
287.85
5
1
0.00184
5
1
7.49e-05
1
295.15
5
1
0.0020053
5
1
8.16e-05
1
297.95
5
1
0.0021274
5
1
8.66e-05
1
303.35
5
1
0.0022675
5
1
9.23e-05
1
308.05
5
1
0.0023752
5
1
9.66e-05
1
313.35
5
1
0.0026229
5
1
0.0001067
1
317.65
5
1
0.0027772
5
1
0.000113
1
323.75
5
1
0.0031644
5
1
0.0001287
4
4
1
1
1
Principal objective of the work
RRP
TRC
1/22/2010
1
Mole fraction
Titration method
1
Liquid
Direct value, X
1
Data file compiler
Propagation of evaluated standard uncertainties
95
Liquid
Crystal
1
1
Pressure, kPa
Liquid
101
3
1
Temperature, K
Liquid
1
273.15
5
1
0.0006028
4
1
2.44e-05
1
278.25
5
1
0.0006781
4
1
2.75e-05
1
281.95
5
1
0.0007346
4
1
2.98e-05
1
287.65
5
1
0.0008249
4
1
3.34e-05
1
292.55
5
1
0.0009792
4
1
3.97e-05
1
297.35
5
1
0.0011033
5
1
4.47e-05
1
302.95
5
1
0.0013402
5
1
5.43e-05
1
307.65
5
1
0.0015056
5
1
6.1e-05
1
312.65
5
1
0.0016559
5
1
6.71e-05
1
317.65
5
1
0.0019189
5
1
7.77e-05
5
5
1
1
1
Principal objective of the work
RRP
TRC
1/22/2010
1
Mole fraction
Titration method
1
Liquid
Direct value, X
1
Data file compiler
Propagation of evaluated standard uncertainties
95
Liquid
Crystal
1
1
Pressure, kPa
Liquid
101
3
1
Temperature, K
Liquid
1
283.15
5
1
2.739e-05
4
1
1.12e-06
1
288.35
5
1
3.682e-05
4
1
1.5e-06
1
293.95
5
1
5.256e-05
4
1
2.14e-06
1
298.15
5
1
6.119e-05
4
1
2.5e-06
1
303.45
5
1
6.97e-05
3
1
2.8e-06
1
311.65
5
1
8.7e-05
4
1
3.55e-06
1
316.85
5
1
0.0001049
4
1
4.3e-06
1
323.65
5
1
0.0001135
4
1
4.6e-06