ABSTRACT

In this work, the solubility of carbamazepine succinic acid cocrystals in ethanol and acetone were measured at (298.15 and 308.15) K at atmospheric pressure. The solubility product (Ksp) which reflects the strength of cocrystal solid-state interactions of carbamazepine (CBZ) and succinic acid (SUC) relative to interactions with the solvent was determined. The solubility data show that significant complexation occurs in some solutions, and the relevant constants are derived. The ternary phase diagrams for the system of CBZ-SUC-ethanol or acetone at (298.15 and 308.15) K, which can provide the theoretical basis for crystallization processes, are presented.

Compounds

#	Formula	Name
1	C15H12N2O	carbamazepine
2	C4H6O4	butanedioic acid
3	C2H6O	ethanol
4	C3H6O	acetone

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	4 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2 Crystal of intercomponent compound 1	spectra	2
POMD	4 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1 Crystal of intercomponent compound 1	spectra	2
POMD	4 2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2 Crystal of intercomponent compound 1	spectra	2
POMD	4 2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1 Crystal of intercomponent compound 1	spectra	2
POMD	4 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	spectra	6
POMD	4 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	spectra	8
POMD	4 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal of intercomponent compound 1	spectra	4
POMD	3 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2 Crystal of intercomponent compound 1	spectra	2
POMD	3 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1 Crystal of intercomponent compound 1	spectra	2
POMD	3 2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2 Crystal of intercomponent compound 1	spectra	2
POMD	3 2 1	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1 Crystal of intercomponent compound 1	spectra	2
POMD	3 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	spectra	6
POMD	3 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	spectra	8
POMD	3 2 1	Mole fraction - 2 ; Liquid	Temperature, K; Liquid Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal of intercomponent compound 1	spectra	4

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solid Liquid Phase Equilibrium and Phase Diagram for the Ternary Carbamazepine Succinic Acid Ethanol or Acetone System at (298.15 and 308.15) K

Xu, S.[Shenmin], Dang, L.[Leping], Wei, H.[Hongyuan]

ABSTRACT